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Amphetamine is understood to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit different P450 isozymes and various enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes point out slight inhibition of CYP2D6 by amphetamine and small inhibition of CYP1A2, 2D6, and 3A4 by a